13774214275
13774214275
產品中心
產品型號：S0B2366
更新時間：2025-10-11
廠商性質：生產廠家
訪問量：94
服務熱線15855403091
相關文章
Multidrug Resistance Protein 3 （MDR3）, also known as ATP-binding cassette sub-family B member 4 （ABCB4）, is a crucial protein primarily expressed in the canalicular membrane of hepatocytes. It functions as a phosphatidylcholine translocase, transporting this phospholipid from the inner to the outer leaflet of the membrane bilayer and into bile. This process is essential for forming mixed micelles with bile salts, protecting the biliary tree from the detergent-like toxicity of bile salts. MDR3 plays a significant role in bile formation and preventing cholestasis. Mutations in the ABCB4 gene can lead to severe liver disorders, such as Progressive Familial Intrahepatic Cholestasis type 3 （PFIC3）, characterized by early-onset cholestasis, liver fibrosis, and eventual liver failure. Additionally, MDR3 dysfunction has been linked to drug-induced liver injury （DILI） due to its inhibition by certain drugs or their metabolites.
當前位置：
上一個：
返回列表
