FGF9 （fibroblast growth factor 9, FGF9） is one of the fibroblast growth factor （FGF） family members. It is widely distributed in various tissues of human body and involved in bone development, angiogenesis, embryonic development, damage repair, cell apoptosis, nerve regeneration, tumor growth and other physiological and pathological processes, and can effectively promote mitosis and cell growth. Current evidence suggests that FGF9 may play a prominent role not only in bone development and growth of cartilage into bone formation and generation, but also has a significant impact on aspects of ovarian cancer, nerve regeneration, gonadal differentiation, there remains much to be discovered and investigated on the functions and mechanisms of FGF18.