Fibroblast Growth Factors （FGFs） are polypeptides with diverse activities in development and physiology. The mammalian Fgf family can be divided into the intracellular Fgf11/12/13/14 subfamily （iFGFs）, the hormone-like Fgf15/21/23 subfamily （hFGFs）, and the canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20. FGF-19 is secreted from ileal enterocytes similar to a hormone. Endocrine derived hormone FGF-19 has recently emerged as a potential target for the treatment of metabolic diseases. In recognition of the skeletal muscle as an important metabolic organ, it is considered that FGF-19 may also have a role in muscle metabolism and may be a new factor with promising value in the treatment of sarcopenia.